EPIDERMOLISIS AMPOLLOSA SIMPLE PDF

Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed. Onset of the disease is usually at birth. Blistering tendency usually worsens in summertime or in warm weather. The frequency of milia, mild atrophic scarring, focal plantar hyperkeratosis and nail dystrophy is intermediate between that of localized EBS and EBS-DM see these terms , and extracutaneous findings, other than occasional intraoral blistering, are rare.

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N of 1 randomized controlled trials. En: Guyatt G, Rennie D, eds. Chicago: AMA Press The clinical spectrum of epidermolysis bullosa simplex. Br J Dermatol ; The efficacy and cost effectiveness of N of 1 studies with diclofenac compared to standard treatment with nonsteroidal antiinflammatory drugs in osteoarthritis. J Rheumatol ; N of 1 randomized trials for investigating new drugs. Control Clin Trials ; Combining single patient N-of-1 trials to estimate population treatment effects and to evaluate individual patient responses to treatment.

J Clin Epidemiol ; Oral tetracycline vs placebo in epidermolysis bullosa simplex - a double-blind, crossover, randomized controlled trial. Hansen S, Veien NK. Oxytetracycline in epidermolysis bullosa simplex. A double-blind, placebo-controlled trial. J Eur Acad Dermatol Venereol ; Treatment of epidermolysis bullosa simplex EBS with tetracycline. Arch Dermatol ; Tetracycline and epidermolysis bullosa simplex: a double-blind, placebo-controlled, crossover randomized clinical trial.

Aluminum chloride hexahydrate and blistering in epidermolysis bullosa simplex. J Am Acad Dermatol ; Fine JD, Johnson L. Evaluation of the efficacy of topical bufexamac in epidermolysis bullosa simplex. A double-blind placebocontrolled crossover trial. Pai S, Marinkovich MP. Epidermolysis bullosa: new and emerging trends. Am J Clin Dermatol ;

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NCBI Bookshelf. Epidermolysis bullosa simplex EBS is characterized by fragility of the skin and mucosal epithelia in some cases that results in non-scarring blisters and erosions caused by minor mechanical trauma. The current classification of epidermolysis bullosa EB includes two major types and 17 minor subtypes of EBS; all share the common feature of blistering above the dermal-epidermal junction at the ultrastructural level. The phenotypes for these subtypes range from relatively mild blistering of the hands and feet to more generalized blistering, which can be fatal.

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Epidermolysis Bullosa Prognosis & Life Expectancy

N of 1 randomized controlled trials. En: Guyatt G, Rennie D, eds. Chicago: AMA Press The clinical spectrum of epidermolysis bullosa simplex. Br J Dermatol ;

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Epidermolysis bullosa

Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed. Localized epidermolysis bullosa simplex, formerly known as EBS, Weber-Cockayne, is a basal subtype of epidermolysis bullosa simplex EBS, see this term. The disease is characterized by blisters occurring mainly on the palms and soles, exacerbated by warm weather. About two-thirds of EBS patients have the localized basal form. Onset is usually in late infancy or early childhood.

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The outlook for children with epidermolysis bullosa EB depends very much on the disease type they inherited. Some forms are mild and even improve with age, while others are so severe that a child is unlikely to live into adulthood. Fortunately, the milder forms are most common. No matter which type a child has, symptoms are often noticeable early in life. Because EB is an inherited disease without a cure, it is currently considered a lifelong condition.

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