ANTAGONISTAS GNRH PDF

Knobil E. The hypothalamic gonadotrophic hormone releasing hormone GnRH pulse generator in the rhesus monkey and it is neuroendocrine control. Hum Reprod ;3 1 Development and applications of luteinizing hormone-releasing hormone antagonists in the treatment of infertility: an overview. Hum Reprod ;10 8 Felberbaum R, Diedrich K.

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The ability of a Nal-Lys gonadotropin releasing-hormone antagonist Antide to suppress pituitary-testicular function and male sexual behavior was studied in seven group-living adult male rhesus monkeys. For four weeks before and eight weeks after Antide treatment, blood samples and behavioral observations were collected three times weekly in a member heterosexual group.

Circulating LH and T were significantly reduced within 24 h following Antide, and remained significantly lower than pretreatment levels in all males for 5 weeks after Antide. Both LH and T returned to pretreatment levels by seven weeks post-Antide and then showed a second significant decrease during the eighth study week.

Pituitary responsiveness to exogenous GnRH was reduced by Antide and remained below pretreatment levels eight weeks after Antide treatment. Testosterone secretion in response to exogenous GnRH was significantly reduced at two and four weeks post-Antide, but was at pretreatment levels by eight weeks after Antide.

Male sexual behavior declined significantly within one week after Antide treatment, almost ceased completely by four weeks after Antide, and returned to pretreatment levels by seven weeks post-Antide. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Search: Search.

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Similar articles Inhibition of pituitary gonadotropin secretion by the gonadotropin-releasing hormone antagonist antide. Development of an in vitro bioassay for characterization of pharmacokinetics and pharmacodynamics of antide in circulation.

Danforth DR, et al. PMID: Sexual maturation in male rhesus monkeys: importance of neonatal testosterone exposure and social rank.

Mann DR, et al. J Endocrinol. Effects of neonatal testicular suppression with a GnRH antagonist on social behavior in group-living juvenile rhesus monkeys.

Wallen K, et al. Horm Behav. Extended presence of antide Nal-Lys GnRH antagonist in circulation: prolonged duration of gonadotropin inhibition may derive from antide binding to serum proteins.

J Clin Endocrinol Metab. Endocrine-immune interaction: alteractions in immune function resulting from neonatal treatment with a GnRH antagonist and seasonality in male primates.

Am J Reprod Immunol. PMID: Review. Show more similar articles See all similar articles. Cited by 3 articles Environmental and social influences on neuroendocrine puberty and behavior in macaques and other nonhuman primates. Stephens SB, Wallen K. Stephens SB, et al. Pubertal development and behavior: hormonal activation of social and motivational tendencies. Forbes EE, et al. Brain Cogn. Epub Nov Sexual communication between breeding male and female cotton-top tamarins Saguinus oedipus , and its relationship to infant care.

Ziegler TE, et al. Am J Primatol. Publication types Research Support, Non-U. Gov't Actions. Research Support, U. Gov't, Non-P. Gov't, P. MeSH terms Animals Actions.

Macaca mulatta Actions. Male Actions. Substances Oligopeptides Actions. Gonadotropin-Releasing Hormone Actions. Testosterone Actions. Luteinizing Hormone Actions. Full-text links [x] Elsevier Science. Copy Download.

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Gonadotropin-releasing hormone antagonist

Para el futuro quedan algunas interrogantes. En cuanto a lo primero, el incremento de precio atribuible al antagonista frente al agonista puede verse compensado por la menor cantidad de gonadotrofinas utilizadas. Facultat de Medicina-Universitat de Barcelona. Analogues de la gonadoliberine. Fertil Steril ; Single and multiple dose pharmacokinetics and pharmacodynamics of the gonadotrophin-releasing hormone antagonist Cetrorelix in healthy female volunteers. Hum Reprod ; Abarelix-depot, a potent pure GnRH antagonist, rapidly induced sustained suppression of the pituitary-gonadal axis in women with endometriosis.

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ANTAGONISTAS GNRH PDF

The ability of a Nal-Lys gonadotropin releasing-hormone antagonist Antide to suppress pituitary-testicular function and male sexual behavior was studied in seven group-living adult male rhesus monkeys. For four weeks before and eight weeks after Antide treatment, blood samples and behavioral observations were collected three times weekly in a member heterosexual group. Circulating LH and T were significantly reduced within 24 h following Antide, and remained significantly lower than pretreatment levels in all males for 5 weeks after Antide. Both LH and T returned to pretreatment levels by seven weeks post-Antide and then showed a second significant decrease during the eighth study week. Pituitary responsiveness to exogenous GnRH was reduced by Antide and remained below pretreatment levels eight weeks after Antide treatment.

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Gonadotropin-releasing hormone antagonists GnRH antagonists are a class of medications that antagonize the gonadotropin-releasing hormone receptor GnRH receptor and thus the action of gonadotropin-releasing hormone GnRH. They are used in the treatment of prostate cancer , endometriosis , uterine fibroids , female infertility in assisted reproduction , and for other indications. Some GnRH antagonists, such as cetrorelix , are similar in structure to natural GnRH a hormone made by neurons in the hypothalamus but that have an antagonistic effect, while other GnRH antagonists, such as elagolix and relugolix , are non-peptide and small-molecule compounds. Testosterone promotes growth of many prostate tumors and therefore reducing circulating testosterone to very low castration levels is often the treatment goal in the management of men with advanced prostate cancer. GnRH antagonists are used to provide fast suppression of testosterone without the surge in testosterone levels that is seen when treating patients with GnRH agonists.

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Optimal usage of the GnRH antagonists: a review of the literature

Intrauterine Insemination. Hum Reprod Update ;15 3 En: Bellver J, Domingo J, ed. Madrid: McGraw-Hill, ;p Ginecol Obstet Mex ; Biblioteca Cochrane Plus, , num.

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