CITICOLINE SODIUM TABLETS PDF

The present invention relates to a kind of C14H25N4NaO11P2 sheet and preparation method thereof, belong to pharmaceutical field. C14H25N4NaO11P2 is used for the treatment of craniocerebral injury and the caused neural sequela of cerebrovascular accident, and can be used for the treatment of parkinson, and senile dementia is also had certain curative effect; Other is as to slow down aging, and improving memory etc. C14H25N4NaO11P2 can increase cerebral blood flow and promote metabolism of brain by reducing cerebral vascular resistance, improves cerebral circulation. Also can strengthen the function of brain stem ARAS ascending reticular activating system , strengthen the function of pyramidal system, improve paralysis motorica, be mainly used in acute craniocerebral trauma and brain operation back disturbance of consciousness, can recover the function of extremity gradually to the hemiplegia due to the apoplexy, also can be used for function and disturbance of consciousness that other central nervous system's acute injuries cause, also be used for ischemic cerebrovascular and vascular dementia.

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The present invention relates to a kind of medicine and preparation method thereof, be specifically related to C14H25N4NaO11P2 sheet and preparation method thereof. C14H25N4NaO11P2 can be by reducing cerebral vascular resistance, and cerebral blood flow increasing promotes metabolism of brain, improves cerebral circulation.

Also can strengthen the function of brain stem ARAS ascending reticular activating system , strengthen the function of pyramidal system, improve paralysis motorica, certain effect be arranged so the recovery of promotion brain function and promotion revived.

C14H25N4NaO11P2 is mainly used in acute craniocerebral trauma and brain operation back disturbance of consciousness, can recover the function of extremity gradually to the hemiplegia due to the apoplexy, also can be used for function and disturbance of consciousness that other central nervous system's acute injuries cause, also be used for ischemic cerebrovascular and vascular dementia.

According to present disclosed patent documentation, as can be seen, at present the research of C14H25N4NaO11P2 is mainly concentrated on the preparation method of C14H25N4NaO11P2, and the preparation method of citicoline sodium dispersible tablets, injection etc. As the Chinese patent publication number is the preparation method that the patent of invention of CN discloses a kind of C14H25N4NaO11P2, mainly be to be biocatalyzer with the yeast, with 5 '-cytidylic acid, phosphocholine, potassium hydroxide, glucose are that the mode of production that raw material carries out biotransformation is produced preparation.

The Chinese patent publication number is that the patent of invention of CN discloses a kind of citicoline sodium injection for intravenous injection and preparation method thereof, its disclosed citicoline sodium injection for intravenous injection, comprise following component in weight portion : C14H25N4NaO11P2 0. The Chinese patent publication number is that the patent of invention of CN discloses a kind of citicoline sodium dispersible tablets and preparation method thereof, and its dispersible tablet comprises C14H25N4NaO11P2 and medicine acceptable carrier such as lactose, starch, cellulose or the like.

But as injection, its production cost height portably uses and is not easily, and physical and chemical properties of drugs is not very stable. The object of the present invention is to provide a kind of tablet output height, cost low; Divided dose accurately, carry with easy to use; The C14H25N4NaO11P2 sheet that physical and chemical properties of drugs is more stable, storage period is long.

Further scheme is that the pregelatinized Starch consumption is 1 to 5g, and the carboxymethylstach sodium consumption is 2 to 8g. Determine that by citicoline sodium content in the always mixed granule of mensuration intermediate sheet is heavy, the tablet divided dose that the present invention is prepared is more accurate, the stability and the suitability that improve product.

In prescription, add pregelatinized Starch through the test of many times proof and can significantly improve particulate uniformity, increased the fineness of particulate relaxed and comfortable degree and label outward appearance, thereby improved the presentation quality and the tablet weight variation quality of C14H25N4NaO11P2 sheet.

In addition, carboxymethylstach sodium adds in this prescription as disintegrating agent, and the rapid disintegrate of quickening this product improves the dissolution rate of this product, improves the inherent quality of this product. As showing impurity peaks, measure each impurity peak area sum in the chromatogram of need testing solution, must not be greater than the peak area 1.

Get above-mentioned two kinds of solution,, measure trap respectively, calculate every stripping quantity at the wavelength place of nm according to spectrophotography two appendix IVA of Chinese Pharmacopoeia version in The test of chromatographic condition and system suitability is a filler with the octadecylsilane chemically bonded silica, with potassium dihydrogen phosphate get the 2.

By external standard method promptly with calculated by peak area. For essence of the present invention better is described, will illustrate that below its physical and chemical properties of drugs is stable, storage period is long with the long-term stable experiment of the prepared C14H25N4NaO11P2 sheet of the present invention.

Get three batches of the C14H25N4NaO11P2 sheets that embodiment one to three makes, lot number is respectively: ,, Instrument: ultraviolet-uisible spectrophotometers limited company of Shanghai spectral instrument , the intelligent dissolution test instrument of ZRS-8G Radio Factory of Tianjin Univ.

Reagent: potassium dihydrogen phosphate: Tianjin lucky star chemical reagent factory; Triethylamine: Chongqing, Shen, Chongqing chemical reagent factory; Phosphoric acid: Chengdu chemical reagent factory; Methanol: import; Redistilled water: self-control. Investigation project: character, dissolution, related substance, sign content, limit test of microbe.

Plastic-aluminum aluminum packing, long-term stable experiment under the normal temperature condition. Address after : No. Patentee after : Sichuan zitonggong pharmaceutical Limited by Share Ltd. Patentee before : Sichuan Zitonggong Pharmaceutical Co.

The invention provides citicoline sodium tablets which are medicinal preparations for treating sequela of a nervous system caused by a craniocerebral injury or a cerebrovascular accident, and a preparation method thereof.

Every 1, tablets comprise The preparation method of the citicoline sodium tablets mainly comprises the steps of sieving, weighing, proportioning, premixing, preparing a soft material, preparing wet granules, drying, granulating, mixing, tabletting, performing aluminum-plastic-aluminum packaging and outer packaging and the like.

The tablets prepared by the method have the advantages of high yield, low cost, accurate divided dose, relatively stable medicinal physicochemical property and longer storage period and are convenient to carry and use. Summary of the invention The object of the present invention is to provide a kind of tablet output height, cost low; Divided dose accurately, carry with easy to use; The C14H25N4NaO11P2 sheet that physical and chemical properties of drugs is more stable, storage period is long.

Carboxymethylstach sodium 0 is to The invention also discloses the preparation method of described C14H25N4NaO11P2 sheet, comprise the steps: 1 gets the raw materials ready: C14H25N4NaO11P2 was pulverized mesh sieves, hydroxypropyl emthylcellulose is mixed with 1. Quality standard test method of the present invention: 1 the related substance precision takes by weighing this product fine powder an amount of being equivalent to C14H25N4NaO11P2 50mg approximately , adds the mobile phase dissolving, filters, and gets subsequent filtrate and makes the solution that every 1ml contains C14H25N4NaO11P2 0.

The preparation method of above-mentioned C14H25N4NaO11P2 sheet comprises the steps: 1 gets the raw materials ready: C14H25N4NaO11P2 was pulverized mesh sieves, starch, microcrystalline Cellulose and magnesium stearate are crossed mesh sieves, hydroxypropyl emthylcellulose is mixed with 2.

Test basis: " national drug standards " trying YBH Content of the test and condition Plastic-aluminum aluminum packing, long-term stable experiment under the normal temperature condition. Long-term stable experiment the results are shown in Table 1 to 3. C14H25N4NaO11P2 sheet according to claim 1 is characterized in that: described pregelatinized Starch consumption is 1 to 5g, and the carboxymethylstach sodium consumption is 2 to 8g.

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CN102028664A - Citicoline sodium tablets and preparation method thereof - Google Patents

PleAse note that this medicine may be available in various strengths for each active ingredient listed above. The following is a list of possible side effects that may occur from all constituting ingredients of Citicoline Tablet. This is not a comprehensive list. These side effects are possible, but do not always occur. Some of the side effects may be rare but serious. Consult your doctor if you observe any of the following side effects, especially if they do not go away.

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Citicoline Sodium

Citicoline INN , also known as cytidine diphosphate-choline CDP-Choline or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline , a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs. Studies suggest that CDP-choline supplements increase dopamine receptor densities. Citicoline is available as a supplement online and in stores. A review of published clinical trials of citicoline noted that while some studies have demonstrated positive effects of the compound on cognition, other studies have failed to confirm these results and additional clinical trials would be needed to confirm any potential benefits of citicoline. Despite some suggestions that citicoline may reduce the rates of death and disability following an ischemic stroke , [10] [11] the largest citicoline clinical trial to date, a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke in Europe, enrolling patients, found no benefit of administering citicoline on survival or recovery from stroke.

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Citicoline Sodium Tablets

The present invention relates to a kind of medicine and preparation method thereof, be specifically related to C14H25N4NaO11P2 sheet and preparation method thereof. C14H25N4NaO11P2 can be by reducing cerebral vascular resistance, and cerebral blood flow increasing promotes metabolism of brain, improves cerebral circulation. Also can strengthen the function of brain stem ARAS ascending reticular activating system , strengthen the function of pyramidal system, improve paralysis motorica, certain effect be arranged so the recovery of promotion brain function and promotion revived. C14H25N4NaO11P2 is mainly used in acute craniocerebral trauma and brain operation back disturbance of consciousness, can recover the function of extremity gradually to the hemiplegia due to the apoplexy, also can be used for function and disturbance of consciousness that other central nervous system's acute injuries cause, also be used for ischemic cerebrovascular and vascular dementia.

MOAC 70-410 PDF

CN103191079A - Citicoline sodium tablet and preparation method thereof - Google Patents

Medically reviewed by Drugs. Last updated on Feb 14, There is mounting evidence for choline's place in therapy for stroke, brain and spinal cord injury, cognitive deficits, and glaucoma; however, results in clinical trials have been inconsistent. Oral dosages of to 2, mg daily have been evaluated in adolescents and adults in clinical trials. Lower doses mg twice daily have been used in short-term trials 6 weeks with combination therapy in patients with major depressive disorder. Information regarding safety and efficacy in pregnancy and lactation is lacking at dosages above those usually taken nutritionally.

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