Male germ cells have a unique morphology and function to facilitate fertilization. Sperm deoxyribonucleic acid DNA is highly condensed to protect the paternal genome during transfer from male to oocyte. Sperm cells undergo extensive epigenetic modifications during differentiation to become a mature spermatozoon. Epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling are substantial regulators of spermatogenesis.

Author:Dunris Daigul
Language:English (Spanish)
Published (Last):25 September 2019
PDF File Size:5.2 Mb
ePub File Size:4.32 Mb
Price:Free* [*Free Regsitration Required]

Dates Publication Date : December 1, Year , Volume 8 , Issue 3, Pages 29 - 35 Zotero Mendeley EndNote. Epigenetic Mechanisms and Hepatocellular Carcinoma. Epigenetic mechanisms provide heritable changes in gene expression and chromatin organization in the eukaryotic cells. Abnormal epigenetic mechanisms particularly play a key role in many different diseases, such as hepatocellular carcinoma. Hepatocellular carcinoma HCC is both genetic and epigenetic disease and is located in the third place in cancer related deaths worldwide.

Hepatocarcinogenesis is constituted by a complex, multistep process. These mechanisms can affect directly the expression of oncogenes, tumor suppressor genes and other tumor-related genes and alter the pathways in cancer development. Furthermore, down-regulation of these genes in HCC is induced by promoter hypermethylation or posttranslational deregulation.

The role of these epigenetic mechanisms in hepatocarcinogenesis provide new therapeutic approaches for HCC. In this review, the results of recent studies related with epigenetic mechanisms in the development of hepatocellular carcinoma have been summarized. Hepatocellular carcinoma. Lancet ;— Center MM, Jemal A. International trends in liver can- cer incidence rates. I, Leggett B. A, MacDonald G.

Review of ge- netic and epigenetic alterations in hepatocarcinogene- sis, J. Epigenetic interplay be- tween histone modifications and DNA methylation in gene silencing, Mutat.

Frau M, Feo F. C, Feo F, Pascale R. New insights on the role of epigenetic alterations in hepatocellular carcino- ma. Journal of Hepatocellular Carcinoma ;— Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell ; Calvisi D. S, Conner E. A, Schroeder I, Factor V.

M, Thorgeirsson S. Mecha- nistic and prognostic significance of aberrant methyla- tion in the molecular pathogenesis of human hepatocel- lular carcinoma, J. Preneoplastic lesions in human hepatocarcinogenesis. Liver Int ;— Bird AP. The relationship of DNA methylation to cancer.

Cancer Surv. Two DNA methyltransferases from murine erythroleukemia cells: purification, se- quence specificity, and mode of interaction with DNA. DNA methyltrans- ferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Bell AC, Felsenfeld G.

Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. Chemopreven- tion by S-adenosyl-L-methionine of rat liver carcinogen- esis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. Role of methionine adenosyltrans- ferase and S-adenosylmethionine in alcohol-associated liver cancer.

Aberrant promot- er methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol ;— Persistent infection of hepatitis B virus is involved in high rate of p16 methylation in hepatocellular carcinoma. Mol Carcinog ;— Clin Cancer Res ;— J Hepatol ;— Mol Carcinogenesis ;— Genome-wide hypomethylation in hepatocellular car- cinogenesis. Cancer Res ;— Allis C. L Epige- netics. Cold Spring Harbor Laboratory Press. The fundamental role of epigenetic events in cancer.

Nat Rev Genet ;— Kouzarides T. Chromatin modifi cations and their func- tion. Cell ;— Herceg Z, Paliwal A. Epigenetic mechanisms in hepa- tocellular carcinoma: how environmental factors infl uence the epigenome.

Mutat Res ;— Schneider R, Grosschedl R. Dynamics and interplay of nuclear architecture, genome organization, and gene expression. Genes Dev ;— High expres- sion of trimethylated histone H3 lysine 4 is associated with poor prognosis in hepatocellular carcinoma. Hum Pathol ;— High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients.

Mol Med ;— Alterations of DNA methylation and histone mod- ifi cations contribute to gene silencing in hepatocellular carcinomas. Hepatol Res ; — Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcino- ma. Anticancer Res ;— Epigenetics in cancer.

Car- cinogenesis ; 27— SMYD3 encodes a histone methyltransferase in- volved in the proliferation of cancer cells. Nat Cell Biol ;— Mattick J. S, and Makunin I. Non-coding RNA. Bartel DP. MicroRNAs: genomics, biogenesis, mecha- nism, and function. Anticancer Agents Med Chem ;— Parasramka M. K, Patel T. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.

Kevin W. Ng, Anderson C, Erin A. Marshall, Brenda C. Minatel, Katey S. Enfield, Heather L. Saprunoff, Wan L. Lam and Victor D. Piwi-interacting RNAs in cancer: emerging functions and clinical utility. Molecular Cancer ; Environmental epigenetics: prospects for studying epigenetic mediation of exposure response re- lationships.

Hum Genet ; —


The role of epigenetics in spermatogenesis Epigenetigin spermatogenezdeki rolu

Alberts, B. Molecular Biology of Cell. New York. Anderson, O.



Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Epigenetic mechanisms in the development of psychiatric disorders Epigenetics is defined as the study of heritable changes of gene function that occur without a change in the nucleotide sequence of DNA.


Psikiyatrik Hastal›klar›n Gelifliminde Epigenetik Mekanizmalar




Related Articles