FORMULASI SEDIAAN TRANSDERMAL PDF

Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above. Fullscreen Fullscreen Off. The effectivity of a topical drug therapy was influenced by its ability to penetrate into skin.

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Ibuprofen is an anti-inflammatory class of non-steroidal propionic acid used in the treatment of osteoarthritis, analgesics, and antipyretics. Ibuprofen made in a transdermal patch to avoid side effects of irritation to the stomach, first pass effect on application oral. This aims of the research to determine the physical characteristics of the patch, the effect of propylene glycol concentration mg, mg, mg on the thickness patch, pH, and the rate of penetration as increase in penetration of the ibuprofen transdermal patch.

Patch preparations were made in 3 draft formulas with varying concentrations of propylene glycol mg, mg, and mg. The method used for penetration testing is Franz diffusion cells. Increasing the concentration of propylene glycol causes an increase medicine that penetrate the skin.

Katzung, B. Waranugraha, Y. Jurnal Kedokteran Brawijaya, ; 26 2. Madhulatha, A. Gungor, S. Plasticizer in Transdermal Drug Delivery System. Recent Advances in Plasticizer. Beyazit-Istanbul: Turki. Williams, A. Penetration Enhancers. Advanced Drug Delivery Reviews. Rowe, R. Handbook of Pharmaceutical Excipients Sixth Edition. Pharmaceutical Press: London. Mehsen, M. AJPS, ; 9 No. Zakinah, H.

Fakultas Farmasi Universitas Jember. Gaikwad, A. Comprehensive Journal of Pharmaceutical Science, ; 1 1. Wulandari, S. User Username Password Remember me. Islamic Pharm. Reference Management. Abstract Ibuprofen is an anti-inflammatory class of non-steroidal propionic acid used in the treatment of osteoarthritis, analgesics, and antipyretics. Keywords: Ibuprofen, transdermal patch, propylene glycol.

References Katzung, B. Beyazit-Istanbul: Turki Williams, A. Remember me.

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Ibuprofen is an anti-inflammatory class of non-steroidal propionic acid used in the treatment of osteoarthritis, analgesics, and antipyretics. Ibuprofen made in a transdermal patch to avoid side effects of irritation to the stomach, first pass effect on application oral. This aims of the research to determine the physical characteristics of the patch, the effect of propylene glycol concentration mg, mg, mg on the thickness patch, pH, and the rate of penetration as increase in penetration of the ibuprofen transdermal patch. Patch preparations were made in 3 draft formulas with varying concentrations of propylene glycol mg, mg, and mg. The method used for penetration testing is Franz diffusion cells. Increasing the concentration of propylene glycol causes an increase medicine that penetrate the skin.

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Mandal SC. Current status and future prospects of new drug delivery system. Pharm Times. Vol 42 4 :

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Tujuan penelitian ini adalah melakukan formulasi dan evaluasi sediaan dengan rute alternatif lain penggunaan kalium diklofenak melalui transdermal patch. Patch dibuat dengan metode penguapan pelarut. Polivinil pirolidon PVP digunakan sebagai polimer untuk pembentukan patch transdermal kalium diklofenak dengan dibutil ftalat DBP sebagai plasticizer dan mentol sebagai peningkat penetrasi. Uji in vitro dilakukan dengan alat difusi modifikasi Franz dan ditentukan dengan spektroskopi UV-sinar tampak. Kadar zat aktif, berat, ketebalan dan organoleptis dari patch juga ditentukan. Kata Kunci : Transdermal; Patch; kalium diklofenak; mentol.

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