Journal of Toxicology and Environmental Healt. Part B. Vale J A. Toxicology Letters. Organophosphorous Poisoning Acute. Clinical Evidence.
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Organophosphorates: acute intoxication practical issues. ISSN Every day more organic phosphorus insecticides, are used in the entire world. Intoxications happen generally accidentally for exhibition work, or intentional as suicides. Organic phosphorus compounds, produces toxic effects, through the inhibition of the acetylcholinesterase, the enzyme responsible for the hydrolisys of the acetylcholine, neurotransmisor producing acetic acid and colina, chemically inert products.
The binding between the organic phosphorus compounds and the acetylcholine is spontaneously and irreversible, however, it can be reversible with the use of an antidote specific called oximas. The early administration of pralidoxima is crucial, great benefits are obtained if it begins in the first six hours after the acute intoxication.
Atropine produces a dramatic clinical benefit for the symptoms muscarinic of the syndrome cholinergic. Important complications happen in the patients with organic phosphorus compounds poisoning, such as hypotension, fatal heart arrhythmias, intermediate syndrome of breathing distress and pneumonia are frequent and severe brain dysfunction.
Keywords : poisoning; toxic substances; oximas; hidrolysis; pralidoxime compounds. Services on Demand Article. Spanish pdf Article in xml format Article references How to cite this article Automatic translation Send this article by e-mail. Ciudad Universitaria Carrera 30 No.
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Intoxicación por organofosforados
Organic phosphorus compound- nerve agents. Crit Care Clin ; 21 4 : De Bleecker J. The Intermediate syndrome in organophosphate poisoning: An Overview of experimental and clinical observations. J Toxicol Clin Toxicol ; 33 6 :
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