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A simple and time-efficient method, based on capillary zone electrophoresis, was developed for the simultaneous determination of bromhexine BMX and amoxicillin AMX in pharmaceutical formulations. The optimized electrophoretic conditions comprise 50 mM sodium phosphate plus 50 mM citric acid as running buffer pH 3.
The analytes were separated in less than 5 min. Formulation samples were processed by successive treatment with methanol, hydrochloric acid, filtering and dilution in the running buffer. Loperamide was used as internal standard for quantitation. Moreover, it was successfully employed for the determination of BMX and AMX in several pharmaceutical formulations, demonstrating its applicability to the routine quality control. Rosestein Ster, E. Li, Y. B , , Okamoto, H. Journal of the Mexican Chemical Society J.
Vol 64, No 2 Quarterly publication April-June. Barranca del Muerto 26, Col. Indexed Journal. Certificate of lawful title and content: Under procedure. Total or partial reproduction is prohibited without written permission of the right holder. Skip to main content Skip to main navigation menu Skip to site footer. Keywords: Capillary electrophoresis, amoxicillin, bromhexine, loperamide, oral suspension.
Abstract A simple and time-efficient method, based on capillary zone electrophoresis, was developed for the simultaneous determination of bromhexine BMX and amoxicillin AMX in pharmaceutical formulations. Altria, K. A , , Anastos, N. Talanta , 67, Hong, W. Drug Discovery Today: Technologies , 2, Thanh, P. Hernandez, M. B , , Santos, S. Talanta , 71, Pajchel, G. Bailon, M. Perez-Ruiz, T. J Chromatogr. Berzas, J. Vol 55 No 2 : Regular Issue. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work e.
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